NIOD CAIL Copper Amino Isolate Lipid Reviews

It´s been a while since we had something new from NIOD, the big sister brand to The Ordinary. Today we saw the launch of NIOD CAIL Copper Amino Isolate Lipid 1%.

Please note that it was only launched today and are awaiting reviews of NIOD CAIL by the mods and the Deciem Addicts.

  • What is NIOD CAIL?
  • What does it do?
  • How much is it?
  • Which products conflict with CAIL?
  • When & how to use it?
  • Lots of Q&As from Instagram
NIOD CAIL Coming Soon

CAIL featured on the Deciem website quite a while ago and was then removed. I have found this explanation by Brandon that featured on an old post in Facebook. “A final note to say that NIOD’s CAIL, the updated edition of CAIS 5%, has been delayed because our lab’s humble and lovely Prudvi has made a new discovery to make CAIL better. Like you, I now can’t wait for springtime. Hug, Brandon”.

What is NIOD CAIL?

Deciem says: Copper Amino Isolate Lipid (CAIL) 1% is the latest addition to NIOD’s core regimen collection. Designed for PM use, the formula has a blue gel-like texture that melts into a comfortable oil-like feel upon application.

An enhanced approach to targeting overall healthy-looking skin, this pro-collagen, pro-lipid, pro-fat formula branches from the concept of NIOD’s multi-award-winning Copper Amino Isolate Serum, with the additional benefits of building and enhancing skin barrier function, elasticity and integrity via lipophilic pathways.

In general, healthy-looking skin maintains a careful balance of glycosaminoglycans (GAGs), extracellular proteins such as collagen and elastin, and epidermal surface lipids, corneocytes, adipocytes, and sebocytes. CAIL 1% is designed with a highly focused effort to target all of the aforementioned skin components, improving volume and resilience by elevating the skin to optimal conditions. Continue to read all about NIOD CAIL here including all ingredients.

What does it do?

Looking at this list, it´s probably easier to say what it doesn’t do. It sounds absolutely amazing.

  • Targets overall healthy-looking skin
  • Enhancing skin barrier function & elasticity
  • Palmitoyl-GHK-Cu This peptide works synergistically to restore and maintain a youthful appearance of the skin. 
  • GHK-Cu has a wide range of skin health functions, including healing, immune function, collagen synthesis, fibroblast production and anti-inflammatory responses. 
  • Zizanoic Vetiver has properties to support skin tonicity, volume and firmness. 
  • Zizanoic Vetiver promotes the improved appearance of skin volume redefinition and firmness while promoting an overall plumping effect.
  • Aphanizomenon Aquaflo A newly-discovered blue-green algae that is rich in vitamins, amino acids, and minerals to promote the replenishment of the superficial protective barrier of the stratum corneum. 
  • Smoothens the skin surface for a younger appearance by facilitating the skin’s natural moisturizing factors.
  • Plant-derived Squalane maintain skin’s moisture barrier, squalane is an excellent hydrator that can replenish hydration, imparting suppleness and flexibility to the skin.

When Do I Use NIOD CAIL?

NIOD CAIL Copper Amino Isolate Serum is listed as part of the Core Regimen and should be applied to the face or face and neck in the evenings. If irritation occurs, cease use and consult a physician. Use only as directed on unbroken skin. Patch testing prior to use is advised.

What products conflict with NIOD CAIL?

Deciem have mentioned on Instagram the following products that should be avoided in the same routine as NIOD CAIL. You can either alternate your products morning / evening or nights.

  • Retinoids
  • Strong Antioxidants
  • Direct Acids
  • Retinoids
  • Pure Vitamin C

How much is NIOD CAIL, Copper Amino Isolate Lipid?

Prices are as follows for 15ml 90$ CAD | 90$US | 70GBP | 135$AUD | 80€.

Why is NIOD CAIL so expensive?

Deciem say that copper peptides are very expensive therefore, it ´s reflected in the price. Normally Deciem release new products and later on you will find them at other stockists where you can often find NIOD discounts.

How long will CAIL LAST?

Deciem say that you could get up to 139 applications if using on your face alone. This seems quite a lot for 15ml but it´s made me wonder if we´ve all be slapping way more of The Ordinary on that is actually necessary.

They have also mentioned that NIOD CAIL has been designed to be used alone straight after cleansing. Many people layer lots of products, but how easy would it be to just cleanse and apply CAIL and let it get to work on your skin? I really feel that this should be taken into consideration. Think of all the time you will save, although I know for some of you, it´s your time to pamper yourself.

The price has been questioned a lot. There was obviously a call for a product like this, otherwise they wouldn´t make it and it´s only fair to try and cater to everyone. Those who use NIOD love it. It is more expensive that The Ordinary, but do have a think about how many 30ml bottles you currently have in your cupboard. They all add up in price, take time to apply, not to mention the space they all take up.

So, before thinking, wow that´s expensive, break it down. Even if you managed to get 100 applications say that´s 70p an application which does sound a lot still, it´s just one product in the evening, cutting out all the different layers you normally use and if it truly works, then I´m all in for a simpler regimen.

My advice is to read many reviews by your favourite bloggers, vloggers but most importantly by the Deciem Addicts in the Facebook Group who have bought, tried and tested. Products feel very differently when you don´t have to spend your hard earned cash on them.


Reviews coming soon by the Moderators of the Facebook Group and the Deciem Addicts.


How many applications can I expect from this?

Deciem say the tube can be expected to last for approximately 139 applications if applied to face only. Should last 56 applications if applied nightly to the face as well as the neck.

What skin type is NIOD CAIL suitable for?

Deciem say CAIL 1%is suitable for all skin types

When would this be used instead of CAIS?

Deciem suggest applying CAIS in the AM and CAIL 1% in the PM ideally.

What is the difference between CAIL and CAIS?

CAIL1% encompasses all the benefits of CAIS 2:1 with the additional benefits of building and enhancing skin barrier function, elasticity and integrity via lipophilic pathways.

How often would you recommend using it?

We recommending applying nightly to face and neck.

Can CAIL be used instead of Buffet with Copper? Can it be combined with Retinol?

Deciem suggest applying Buffet + Copper in the AM and CAIL in the PM. Avoid Retinoids when using CAIL.

Is this gentle enough to be applied under the eyes?


Can I apply this in the morning as I have tretinoin in the evening?

Yes you may.

Does Cail work well with acids?

CAIL 1% should not be used within the same routine as products containing strong antioxidants, direct acids or pure vitamin c.

Can this be used on top of serums or is it best used alone?

It can be used alone or with other serums.

So does this go first in the regimen followed by other products?


Can I use CAIS with CAIL?

It is not necessary to use both within the same routine.

Is CAIL advisable for Oily / Acne prone skin?

Deciem say it´s suitable for all skin types.

Is CAIL Vegan friendly


Is CAIL good for someone who has acne problems?

This formula is oil-free and suitable for all skin types but does not directly target signs of congestion.

Does CAIL help under hollows of eyes? Can I use it there?

Yes it can be applied to the eye contours.

Can CAIL be used with NIOD RP, ELAN or NAAP?

CAIL cannot be used with Direct acids, antioxidants, pure vitamin C, retinoids, retinals or NAAP.

I´m currently using the NIOD Core Regimen. what would the order be?

NIOD FECC followed by CAIL, MMHC2, HV, NEC as part of the evening routine

What constitutes a direct acid? Can CAIL or CAIS be used with Resveratrol / Ferulic Acid or Alpa Lipoic Acid.

CAIL should not be used with Alpha Lipoic or Resveratrol

How can a pea size cover the whole face?

CAIL 1% has great spreadability and only a small pea size amount is necessary for application to the full face.

Can I use CAIL after micro needling?

Deciem say their products have not been tested for use with micro needling treatments. They strongly advise patch testing.

What age groups would you say this product is most beneficial for? Would you recommend it for someone in their mid 20s?

CAIL 1% can be used by anyone who is looking to target various signs of ageing.

Can it be used with NIOD RP Re Pigment?


Other Deciem Copper Products

If you´re looking for more affordable Deciem products containing copper, have a look at The Ordinary Buffet + Copper Peptides, and NIOD CAIS Copper Amino Isolate Serum. Both get amazing reviews.

Make sure you´re part of the Facebook Group The Ordinary & Deciem Chat Room for all the latest news and reviews by the Deciem Addicts. If you´re not on Facebook, don´t worry, join in on the conversation about NIOD CAIL on Instagram.

Buy NIOD at Deciem with free delivery on orders over 25€$