NIOD CAIS3 Copper Amino Isolate Serum 3 1:1

Quick look at CAIS3 1:1

• Use AM & PM
• Use this directly after cleansing and before any oils or creams
• Avoid acids, pure vitamin c, retinol and strong antioxidants in the same routine
• Available in 2 sizes 15ml & 30ml
• US/CAD 60$ | 90$
• GBP  £38 |  £60
• AUD $90 | 135$
• For all other currencies, please check the website

NIOD CAIS3 1:1 Pictures & Video of Product

See the product, the colour and viscosity before buying.

About NIOD CAIS3

How To Use NIOD CAIS 3

• Apply to face morning and evening.
• Apply as the first step after cleansing.

NIOD CAIS 3 1:1 Conflicts

Avoid the following products in the same routine. You can alternate them morning/evening or on different days.

• Acids
• Pure Vitamin C
• Retinol
• Strong Antioxidants

NIOD CAIS3 PAO

Period after opening is 6 months

Colour

Blue

Solution/Texture

Very thin. Absorbs really quickly.

CAIS 3 1:1  is the third generation of NIOD’s multi-award-winning Copper Amino Isolate Serum. Copper Amino Isolate Serum 3 1:1 replaces Copper Amino Isolate Serum 2:1.

As a highly focused effort to maintain healthy-looking skin, this pro-repair, pro-collagen serum offers a novel approach to target all visible signs of skin aging indirectly. This indirect approach departs from the traditional thinking of addressing visible aspects of skin aging individually and instead forms a foundation to respect skin health.

More about NIOD CAIS3

The previous generation of CAIS contained 2% of pure GHK peptide, of which 1% branched with copper ions upon mixing, forming 1% freshly-assembled, pro-repair GHK-Cu (copper peptides) and leaving 1% free-form, pro-collagen GHK peptide, for a final ratio of 1:1.

The new formula omits mixing, instead of containing 1% concentration by weight of pre-assembled and fully stable GHK-Cu, alongside 1% GHK peptide. Since this formula no longer requires additional GHK peptide for copper complexation, and no other copper source is added, it carries the name CAIS 3 1:1, as a reflection of the ratio of these ingredients in the formulation.

CAIS 3 1:1 also includes additional collagen-supporting peptides, Tripeptide-29, Acetyl Tetrapeptide-2 and Trifluoroacetyl Tripeptide-2. Its base combines mono-dispersed, plant-derived glycogen, availability-enhancing Myristoyl Nonapeptide-3 and cross-linked hyaluronic acid.

 PRO-HEALTH TECHNOLOGIES

1.0% Pure Undiluted Copper Tripeptide-1 (GHK-Cu) + 1.0% Pure Undiluted Tripeptide-1 (GHK)
CAIS 3 1:1 supplies 1% pure GHK peptide (Tripeptide-1), alongside 1% Copper Tripeptide-1 (GHK-Cu). Both GHK and GHK-Cu are found in nature and originally isolated from human plasma. The concentration of these peptides in human plasma continues to drop with aging past late teenage years.The natural role of these peptides as found in the human body includes activation of a wide range of skin health functions, including healing, immune function, collagen synthesis, fibroblast production and anti-inflammatory responses, while pure GHK offers strong pro-collagen support.

The 2% concentration of GHK and GHK-Cu in CAIS 3 1:1 aims to target visible signs of skin aging, including textural irregularities, uneven tone, visibly enlarged pores and a general lack of healthy radiance normally present in younger skin. In short, the skin will look healthier with visible improvements with continued use.

PRO-COLLAGEN TECHNOLOGIES

9.0% Pure Undiluted Tripeptide-29
This amino acid sequence of Glycine-Proline-Hydroxyproline supports healthy collagen and works synergistically with GHK and GHK-Cu in this function.

4.0% Complex of Acetyl Tetrapeptide-2 and Trifluroacetyl Tripeptide-2
While pro-collagen peptides broadly focus on collagen quantity, these advanced peptide technologies support healthy collagen quality and assembly for skin that looks firmer and more evenly modeled.

INTEGRITY AND DELIVERY TECHNOLOGIES

0.10% Pure Mono-Dispersed Plant Glycogen
Glycogen is generally extracted from animal sources as a poly-dispersion. This advanced 100% plant-based mono-dispersed glycogen acts like hard spheres that protect the formulation peptides but break upon application for optimal dermal exposure.

9% Complex of Myristoyl Nonapeptide-3
This lipo-oligopeptide supports healthy skin renewal which is essential for maximizing skin availability of technologies in this formulation and those used in any subsequent treatments.

Hyaluronic Acid Crosspolymer
A unique cross-linked non-animal form of hyaluronic acid helps with the delivery of water and water-soluble actives through its nonequilibrium gel structure.

FAQs about NIOD CAIS3

These questions have been answered by Deciem on Social Media.

Is CAIS3 more potent than CAIS 2:1? Copper Amino Isolate Serum 3 1:1 replaces Copper Amino Isolate Serum 2:1 and offers the same pro-collagen and pro-repair benefits without mixing.

Can I mix NIOD CAIS3 with my Buffet Serum or it’s better to use it alone? You may apply The Ordinary “Buffet” after use. 

Can I use CAIS3 before SubQ Skin? Yes, you may.

MORE FAQS

Can CAIS 3 be used with SDSM? Yes, it can.

Would CAIS3 be used morning or night with retinol (night) or vitamin C (morning)? It can be used twice daily if desired. If you wish to incorporate multiple Vitamin C’s, Retinoids, and/or Direct Acids into your skincare regimen, we suggest using them on alternate evenings and waiting until your skin has adjusted to one before introducing another.

Is CAIS3 the same texture as before or is this formulation thicker? The same texture – ultra lightweight. 

Can CAIS3 be used with NIOD ELAN? We would recommend using in alternate routines.

Is it ok to use CAIS3 with my Retinol? We recommend using CAIS 3 1:1 in the AM and your Retinol in the PM.

Can we use NIOD CAIS3 or 2 in the same routine as Survival0? Yes, you can. You may apply CAIS2 or CAIS3 first.

Can you use CAIS3 with antioxidants like EUK or Pycnogenol, etc? We would recommend using Copper Peptides in alternate routines as strong antioxidants.

More FAQs

So is the mixing version of CAIS no longer going to be available? CAIS 3 1:1 will be replacing the previous formulation.

Is there any change regarding active ingredients concentrations? This formula no longer requires additional GHK peptide for copper complexation. However, the concentration of GHK-Cu is the same. 

Does this help blemish-prone skin? Just as a note – none of our products can be considered medical treatments for acne, so we suggest consulting with your physician to see what may work best for your skin.

Now that there is no more mixing involved with version 3, is the shelf life shorter than with CAIS 2? The shelf life is the same.

Looking forward to trying this out. Have you your similar product from the Ordinary. We hope you love it! You may wish to also explore The Ordinary “Buffet” + Copper Peptides 1%.

NIOD CAIS3 Reviews

Coming soon…

Aqua (Water), Glycerin, Tripeptide-29, Tripeptide-1 Copper Acetate, Tripeptide-1 Acetate, Myristoyl Nonapeptide-3, Trifluoroacetyl Tripeptide-2, Acetyl Tetrapeptide-2, Sodium Hyaluronate Crosspolymer, Glycogen, Propanediol, Pentylene Glycol, Dextran, Dimethyl Isosorbide, Ethoxydiglycol, Isoceteth-20, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.

________________________________________________________________________

NIOD CAIS 2:1 NO LONGER AVAILABLE

• What is NIOD CAIS2:1 and what does it do?
• How to mix NIOD CAIS
• When do I use NIOD Copper Amino Isolate Serum?
• Where does CAIS fit into my routine?
• Are there any products that conflict with NIOD CAIS?
• NIOD CAIS Reviews
• FAQs all about NIOD CAIS
• Other Deciem copper products.
• Where to buy NIOD
• 15 ml CAIS 38GBP |45.60 | 90$AUD |60$ US | 60$CAD
• 30ml CAIS 60GBP | 72€ |135$AUD | 90$ US | 90$ CAD

CAIS 2:1 REVIEWS

• 69% of the Deciem Addicts love it
• 67% say they have seen an improvement
• 80% will repurchase NIOD CAIS

What is NIOD CAIS Copper Amino Isolate Serum and what does it do?

Deciem say: CAIS2 is the second generation of NIOD’s multi-award-winning Copper Amino Isolate Serum. As a highly focused effort to maintain healthy-looking skin, this pro-repair, pro-collagen serum offers a novel approach to target all signs of skin ageing indirectly. This indirect approach departs from the traditional thinking of addressing visible aspects of skin ageing individually and instead forms a foundation to respect skin health. 

• NIOD CAIS targets signs of skin ageing.
• Visible textural damage.
• Uneven tone
• Visibly enlarged pores
• General lack of healthy radiance 
• CAIS will look healthier with continued visible improvements with continued use

How to mix NIOD CAIS Serum

Are there any products that conflict with CAIS?

When using NIOD CAIS it’s best not to use acids, pure vitamin c, retinol or strong antioxidants in the same routine. You can alternate them am/pm.

NIOD CAIS Reviews by the Deciem Addicts

You can read over 143 reviews on the Deciem website. CAIS currently scores 8.2. You can find more reviews on Deciem Chat Room Instagram. There will be positive and negative reviews because these are reviews by the people who have bought, tried, and tested. It´s important to remember, what works for one may not work for you.

Tracy: 48 years. Dry, Sensitive, Ageing Skin I have tried a number of Deciem Peptide products. All of them have their strengths and weaknesses… then I met NIOD CAIS, Copper Amino Isolate Serum. As per all Deciem products, you need to have an attention span to read through and understand all the science-speak. (ok, maybe I’m just speaking for myself) I tried this based on the amazing reviews I read.  First off, the color is gorgeous. (sorry I’m alot about the aesthetic)  Second: the texture is silky, fluid, it absorbs in seconds. LUXURIOUS. Thirdly, the product comes in 2 little bottles. You get to play Mad Scientist by mixing the two to get the magical results. Peptides are wonderful anti-agers, copper helps heal the skin… both are high up on my needs list. Overall, this works for me on all levels.
10/10 would recommend.

More Reviews

I love NIOD CAIS. This product and it is in my night routine for over 4 years.

I think NIOD CAIS is a bit expensive. I bought 2 bottles of CAIS and wasn’t sure of the vinegar smell, but still used it. People did comment on how well I looked. Now I use The Ordinary Buffet with Copper it’s thicker that the CAIS2 which I prefer.

NIOD CAIS is the single most effective skincare product I’ve ever tried.

I never tried Buffet plus copper but I did get my hands on this serum CAIS2 and I´m so disappointed by the results as it did nothing for my skin.

Unfortunately, no difference in my skin despite the 3 bottles used. Very expensive product for little result.

Final thoughts on NIOD CAIS

You can see for yourself this is a well-loved product. The main issue is the price, it is expensive. NIOD is for long term skin health so if you give these products a go, be prepared to repurchase. Many people aren’t consistent and therefore think the product hasn’t worked for them. It is expensive but you can always find up to 22% off with Deciem Chat Room Discounts.

Other Copper Products by Deciem

• NIOD CAIL Copper Amino Isolate Lipid
• The Ordinary Buffet + Copper Peptides

Where to buy NIOD

There are many places to buy NIOD. You can find a whole list of Deciem stores and online stockists here. Deciem offers free delivery on orders over 25€$. You can always find discounts on NIOD of sometimes up to 25%.