NIOD CAIS3 Reviews of The Brand New CAIS3

NIOD CAIS3 Copper Amino Isolate Serum 3 1:1

Today NIOD CAIS3 has just been released and replaces NIOD CAIS2:1. This product is already pre-assembled and fully stable GHK-CU. Deciem says Copper Amino Isolate Serum 3 1:1 replaces Copper Amino Isolate Serum 2:1 and offers the same pro-collagen and pro-repair benefits without mixing.

NIOD CAIS 3

Quick look at CAIS3 1:1

  • Use AM & PM
  • Use this directly after cleansing and before any oils or creams
  • Avoid acids, pure vitamin c, retinol and strong antioxidants in the same routine
  • Available in 2 sizes 15ml & 30ml
  • US/CAD 60$ | 90$
  • GBP  £38 |  £60
  • AUD $90 | 135$
  • For all other currencies, please check the website

NIOD CAIS3 1:1 Pictures & Video of Product

See the product, the colour and viscosity before buying.

About NIOD CAIS3

How To Use NIOD CAIS 3

  • Apply to face morning and evening.
  • Apply as the first step after cleansing.

NIOD CAIS 3 1:1 Conflicts

Avoid the following products in the same routine. You can alternate them morning/evening or on different days.

  • Acids
  • Pure Vitamin C
  • Retinol
  • Strong Antioxidants

NIOD CAIS3 PAO

Period after opening is 6 months

Colour

Blue

Solution/Texture

Very thin. Absorbs really quickly.

CAIS 3 1:1  is the third generation of NIOD’s multi-award-winning Copper Amino Isolate Serum. Copper Amino Isolate Serum 3 1:1 replaces Copper Amino Isolate Serum 2:1.

As a highly focused effort to maintain healthy-looking skin, this pro-repair, pro-collagen serum offers a novel approach to target all visible signs of skin aging indirectly. This indirect approach departs from the traditional thinking of addressing visible aspects of skin aging individually and instead forms a foundation to respect skin health.

More about NIOD CAIS3

The previous generation of CAIS contained 2% of pure GHK peptide, of which 1% branched with copper ions upon mixing, forming 1% freshly-assembled, pro-repair GHK-Cu (copper peptides) and leaving 1% free-form, pro-collagen GHK peptide, for a final ratio of 1:1.

The new formula omits mixing, instead of containing 1% concentration by weight of pre-assembled and fully stable GHK-Cu, alongside 1% GHK peptide. Since this formula no longer requires additional GHK peptide for copper complexation, and no other copper source is added, it carries the name CAIS 3 1:1, as a reflection of the ratio of these ingredients in the formulation.

CAIS 3 1:1 also includes additional collagen-supporting peptides, Tripeptide-29, Acetyl Tetrapeptide-2 and Trifluoroacetyl Tripeptide-2. Its base combines mono-dispersed, plant-derived glycogen, availability-enhancing Myristoyl Nonapeptide-3 and cross-linked hyaluronic acid.

 PRO-HEALTH TECHNOLOGIES

1.0% Pure Undiluted Copper Tripeptide-1 (GHK-Cu) + 1.0% Pure Undiluted Tripeptide-1 (GHK)
CAIS 3 1:1 supplies 1% pure GHK peptide (Tripeptide-1), alongside 1% Copper Tripeptide-1 (GHK-Cu). Both GHK and GHK-Cu are found in nature and originally isolated from human plasma. The concentration of these peptides in human plasma continues to drop with aging past late teenage years.The natural role of these peptides as found in the human body includes activation of a wide range of skin health functions, including healing, immune function, collagen synthesis, fibroblast production and anti-inflammatory responses, while pure GHK offers strong pro-collagen support.

The 2% concentration of GHK and GHK-Cu in CAIS 3 1:1 aims to target visible signs of skin aging, including textural irregularities, uneven tone, visibly enlarged pores and a general lack of healthy radiance normally present in younger skin. In short, the skin will look healthier with visible improvements with continued use.

PRO-COLLAGEN TECHNOLOGIES

9.0% Pure Undiluted Tripeptide-29
This amino acid sequence of Glycine-Proline-Hydroxyproline supports healthy collagen and works synergistically with GHK and GHK-Cu in this function.

4.0% Complex of Acetyl Tetrapeptide-2 and Trifluroacetyl Tripeptide-2
While pro-collagen peptides broadly focus on collagen quantity, these advanced peptide technologies support healthy collagen quality and assembly for skin that looks firmer and more evenly modeled.


INTEGRITY AND DELIVERY TECHNOLOGIES

0.10% Pure Mono-Dispersed Plant Glycogen
Glycogen is generally extracted from animal sources as a poly-dispersion. This advanced 100% plant-based mono-dispersed glycogen acts like hard spheres that protect the formulation peptides but break upon application for optimal dermal exposure.

9% Complex of Myristoyl Nonapeptide-3
This lipo-oligopeptide supports healthy skin renewal which is essential for maximizing skin availability of technologies in this formulation and those used in any subsequent treatments.

Hyaluronic Acid Crosspolymer
A unique cross-linked non-animal form of hyaluronic acid helps with the delivery of water and water-soluble actives through its nonequilibrium gel structure.

FAQs about NIOD CAIS3

These questions have been answered by Deciem on Social Media.

Is CAIS3 more potent than CAIS 2:1? Copper Amino Isolate Serum 3 1:1 replaces Copper Amino Isolate Serum 2:1 and offers the same pro-collagen and pro-repair benefits without mixing.

Can I mix NIOD CAIS3 with my Buffet Serum or it’s better to use it alone? You may apply The Ordinary “Buffet” after use. 

How is CAIS3 different to CAIS2? CAIS 3 1:1 is the third generation of NIOD’s multi-award-winning Copper Amino Isolate Serum. Copper Amino Isolate Serum 3 1:1 replaces Copper Amino Isolate Serum 2:1. The previous generation of CAIS contained 2%% of pure GHK peptide, of which 1%% branched with copper ions upon mixing, forming 1%% freshly-assembled, pro-repair GHK-Cu (copper peptides) and leaving 1%% free-form, pro-collagen GHK peptide, for a final ratio of 1:1. The new formula omits mixing, instead of containing 1%% concentration by weight of pre-assembled and fully stable GHK-Cu, alongside 1%% GHK peptide. Since this formula no longer requires additional GHK peptide for copper complexation, and no other copper source is added, it carries the name CAIS 3 1:1, as a reflection of the ratio of these ingredients in formulation.

Can I use CAIS3 before SubQ Skin? Yes, you may.

MORE FAQS

Can CAIS 3 be used with SDSM? Yes, it can.

Would CAIS3 be used morning or night with retinol (night) or vitamin C (morning)? It can be used twice daily if desired. If you wish to incorporate multiple Vitamin C’s, Retinoids, and/or Direct Acids into your skincare regimen, we suggest using them on alternate evenings and waiting until your skin has adjusted to one before introducing another.


Is CAIS3 the same texture as before or is this formulation thicker? The same texture – ultra lightweight. 

Can CAIS3 be used with NIOD ELAN? We would recommend using in alternate routines.

Is it ok to use CAIS3 with my Retinol? We recommend using CAIS 3 1:1 in the AM and your Retinol in the PM.

Can we use NIOD CAIS3 or 2 in the same routine as Survival0? Yes, you can. You may apply CAIS2 or CAIS3 first.

Can you use CAIS3 with antioxidants like EUK or Pycnogenol, etc? We would recommend using Copper Peptides in alternate routines as strong antioxidants.

Is it ok to use CAIS with The Ordinary Glycolic Toner? We recommend using Copper Peptides in alternate routines as Direct Acids.

More FAQs

So is the mixing version of CAIS no longer going to be available? CAIS 3 1:1 will be replacing the previous formulation.

Is there any change regarding active ingredients concentrations? This formula no longer requires additional GHK peptide for copper complexation. However, the concentration of GHK-Cu is the same. 

Does this help blemish-prone skin? Just as a note – none of our products can be considered medical treatments for acne, so we suggest consulting with your physician to see what may work best for your skin.

Now that there is no more mixing involved with version 3, is the shelf life shorter than with CAIS 2? The shelf life is the same.

Looking forward to trying this out. Have you your similar product from the Ordinary. We hope you love it! You may wish to also explore The Ordinary “Buffet” + Copper Peptides 1%.

NIOD CAIS3 Reviews

Coming soon…

NIOD CAIS3 Ingredients

Aqua (Water), Glycerin, Tripeptide-29, Tripeptide-1 Copper Acetate, Tripeptide-1 Acetate, Myristoyl Nonapeptide-3, Trifluoroacetyl Tripeptide-2, Acetyl Tetrapeptide-2, Sodium Hyaluronate Crosspolymer, Glycogen, Propanediol, Pentylene Glycol, Dextran, Dimethyl Isosorbide, Ethoxydiglycol, Isoceteth-20, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.

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NIOD CAIS 2:1 NO LONGER AVAILABLE

NIOD CAIS Reviews

CAIS 2:1 REVIEWS

  • 69% of the Deciem Addicts love it
  • 67% say they have seen an improvement
  • 80% will repurchase NIOD CAIS

What is NIOD CAIS Copper Amino Isolate Serum and what does it do?

Deciem say: CAIS2 is the second generation of NIOD’s multi-award-winning Copper Amino Isolate Serum. As a highly focused effort to maintain healthy-looking skin, this pro-repair, pro-collagen serum offers a novel approach to target all signs of skin ageing indirectly. This indirect approach departs from the traditional thinking of addressing visible aspects of skin ageing individually and instead forms a foundation to respect skin health. 

  • NIOD CAIS targets signs of skin ageing.
  • Visible textural damage.
  • Uneven tone
  • Visibly enlarged pores
  • General lack of healthy radiance 
  • CAIS will look healthier with continued visible improvements with continued use

How to mix NIOD CAIS Serum

  • First of all NIOD CAIS Copper Amino Isolate Serum comes in a box with 2 bottles. The serum and the activator. It will seem as though one is empty but it´s not. This is the copper activator that will give your product a stunning blue colour.
  • Pour the activator into the Serum bottle. Take your time doing this and make sure the surface is flat and clear to avoid any mistakes.
  • On the NIOD website, it says to pour the activator into the serum bottle. If you watch the video below, they pour the serum into the activator bottle.
  • Once mixed, shake well for 30 seconds and the product will turn blue.
  • Watch the video on how to mix NIOD CAIS here.

When Do I use NIOD CAIS?

  • You can use NIOD CAIS Copper Amino Isolate Serum in the morning and the evening.
  • If you are using products that conflict (check below), you may find you only use this once a day.

Where does NIOD CAIS fit into my routine?

  • CAIS is thinner than water so always go first directly after cleansing.
  • You want to be really careful applying this because it is so thin.
  • A typical NIOD routine would be CAIS > MMHC2 > MG. If you are totally confused by all these names, check the Beginners Guide To NIOD here.
  • Watch the video here.

Are there any products that conflict with CAIS?

When using NIOD CAIS it’s best not to use acids, pure vitamin c, retinol or strong antioxidants in the same routine. You can alternate them am/pm.

NIOD CAIS Reviews

NIOD CAIS Reviews by the Deciem Addicts

You can read over 143 reviews on the Deciem website. CAIS currently scores 8.2. You can find more reviews on Deciem Chat Room Instagram. There will be positive and negative reviews because these are reviews by the people who have bought, tried, and tested. It´s important to remember, what works for one may not work for you.

Tracy: 48 years. Dry, Sensitive, Ageing Skin I have tried a number of Deciem Peptide products. All of them have their strengths and weaknesses… then I met NIOD CAIS, Copper Amino Isolate Serum. As per all Deciem products, you need to have an attention span to read through and understand all the science-speak. (ok, maybe I’m just speaking for myself) I tried this based on the amazing reviews I read.  First off, the color is gorgeous. (sorry I’m alot about the aesthetic)  Second: the texture is silky, fluid, it absorbs in seconds. LUXURIOUS. Thirdly, the product comes in 2 little bottles. You get to play Mad Scientist by mixing the two to get the magical results. Peptides are wonderful anti-agers, copper helps heal the skin… both are high up on my needs list. Overall, this works for me on all levels.
10/10 would recommend.

More Reviews

I love NIOD CAIS. This product and it is in my night routine for over 4 years.

I think NIOD CAIS is a bit expensive. I bought 2 bottles of CAIS and wasn’t sure of the vinegar smell, but still used it. People did comment on how well I looked. Now I use The Ordinary Buffet with Copper it’s thicker that the CAIS2 which I prefer.

NIOD CAIS is the single most effective skincare product I’ve ever tried.

I never tried Buffet plus copper but I did get my hands on this serum CAIS2 and I´m so disappointed by the results as it did nothing for my skin.

Unfortunately, no difference in my skin despite the 3 bottles used. Very expensive product for little result.

NIOD CAIS FAQS

Questions answered by Deciem on social media

Can I use NIOD CAIS whilst I’m pregnant? While each ingredient has been tested and is considered safe for topical application, DECIEM products have not been tested on pregnant or breastfeeding women. We suggest consulting with our full ingredients list and your physician to be absolutely sure. While each ingredient has been tested and is considered safe for topical application, DECIEM products have not been tested on pregnant or breastfeeding women. We suggest consulting with our full ingredients list and your physician to be absolutely sure.

Could you use NIOD CAIL & CAIS?  Deciem suggests applying CAIS in the AM and CAIL Copper Amino Isolate Lipid 1% in the PM ideally.

What is the difference between NIOD CAIS Copper Amino Isolate Serum and CAIL Copper Amino Isolate Lipid? CAIL1% encompasses all the benefits of CAIS 2:1 with the additional benefits of building and enhancing skin barrier function, elasticity and integrity via lipophilic pathways.

Final thoughts on NIOD CAIS

NIOD CAIS Reviews

You can see for yourself this is a well-loved product. The main issue is the price, it is expensive. NIOD is for long term skin health so if you give these products a go, be prepared to repurchase. Many people aren’t consistent and therefore think the product hasn’t worked for them. It is expensive but you can always find up to 22% off with Deciem Chat Room Discounts.

Other Copper Products by Deciem

Where to buy NIOD

There are many places to buy NIOD. You can find a whole list of Deciem stores and online stockists here. Deciem offers free delivery on orders over 25€$. You can always find discounts on NIOD of sometimes up to 25%.